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KMID : 0617319980070010234
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Journal of Pharmacetical Sceiences Ewha Womans University
1998 Volume.7 No. 1 p.234 ~ p.243
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ARTERIAL AND VENOUS BLOOD SAMPLING IN PHARMACOKINETIC STUDIES
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CHUNG, SU Y.
YOON, WOO H./KIM, SO H./HWANG, KWANG-SUH/LEE, MYUNG G.
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Abstract
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The pharmacokinetics of bumetanide were evaluated simultaneously using both arterial and venous plasma data in 4 rabbits after a rapid 5 sec intravenous (iv) bolus dosing. Initial arterial to venous concentration ratios at 5 sec after injection were the highest with the values of 1410, 246, 4.25, and 351 for rabbits 1-4, respectively. Both curves decayed paralleling each other at the terminal phase with the higher venous levels than the arterial levels by 21.6, 48.2, 17.0, and 47.9% for rabbits 1-4, respectively. An exponential term with a negative coefficient was used to account for the short and steep rising phase of venous plasma levels after injection. Detailed analysis showed apparent volume of distribution at steady state (V_ss) and mean residence time (MRT) values calculated from venous plasma data were higher than those form arterial plasma data. A plot of 1/Q (urine flow rate) versus 1/CL_R (renal clearance) of bumetanide yielded a straight line in 4 rabbits, indicating that the CL_R of bumetanide is urine flow dependent in rabbits.
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KEYWORD
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